Gold coins are made mostly or entirely of gold. Gold has been for coins practically since the invention of coinage, originally because of gold's intrinsic value. In modern times, most gold coins are for collectors, or as bullion coins. Gold Bullion Coins whose nominal value is irrelevant and which serve primarily as a method of investing in gold. Gold has been as money for many reasons. It is fungible, meaning that it trades easily, with a low spread between the prices to buy and sell. Gold Coins are easily transportable, as it has a high value to weight ratio, compared to other commodities, such as silver. Gold can be into smaller units, without destroying its value; it melts into ingots, and re-coined. The density of gold is higher than most other metals, making it difficult to pass counterfeits. Gold is extremely un-reactive. The scarcity of gold stabilizes its value. Precious metals in bulk form are bullion, and trade on commodity markets. Bullion metals cast into ingots, or minted into coins. The defining attribute of bullion is that it is valued by its mass and purity rather than by a face value as money. While obsolete gold coins collected for their numismatic value, gold bullion coins today derive their value from the metal content and viewed by some investors as a "hedge" against inflation or a store of value. Many nations mint bullion coins. The European Commission publishes annually a list of gold coins, which are as investment gold coins in all EU Member States. The list has legal force and supplements the law. South Africa introduced the Krugerrand in 1967 to cater to this market; this was the reason for its convenient and memorable gold content — exactly one troy ounce. It was the first modern, low premium gold bullion coin. Bullion gold coins are also in fractions of an ounce – typically half ounce, quarter ounce, and one-tenth ounce. Bullion coins sometimes carry a face value as legal tender, the face value is on the coin, and in order to bestow legal tender status on a coin, which generally makes it easier to import or export across national borders, as well as subject to counterfeiting. However, their real value is as dictated by their troy weight, the current market price of the precious metal contained, and the prevailing premium that market wishes to pay for those particular bullion coins. The face value is always significantly less than the bullion value of the coin. Legal tender bullion coins are a separate entity to bullion gold. One enjoys legal tender status; the latter is merely a raw commodity. Coins are usually made of an alloy as other metals are into the coin to make it more durable. Fineness is the actual gold content in a coin or bar and expressed in grams or troy ounces. Karat weight is a unit of fineness for gold equal to 1/24 part of pure gold in an alloy. Pure gold is 1000 fine. Below is a karat weight to fineness conversion chart. There is a correlation between karats and fineness: 24 karats = 1000 fine, 23 karats = 958.3 fine, 22 karats = 916.6 fine, 21 karats = 875.0 fine, 20 karats = 833.3 fine, 18 karats = 750.0 fine, 16 karats = 666.7 fine, 14 karats = 583.3 fine, 10 karats = 416.6 fine.

Buprenorphine

Buprenorphine is a partial agonist of opioid receptors that carries a low risk of overdose. Buprenorphine reduces or eliminates withdrawal symptoms associated with opioid dependence but does not produce the euphoria and sedation caused by heroin or other opioids. In 2000, Congress passed the Drug Addiction Treatment Act, allowing qualified physicians to prescribe Schedule III, IV and V medications for the treatment of opioid addiction. This bill created a major paradigm shift that allowed access to opioid treatment in general medical settings, such as primary care offices, rather than limiting it to specialized treatment clinics. Buprenorphine was the first medication approved under the Drug Addiction Treatment Act and is available in two formulations: Subutex®, which is a pure form of buprenorphine and the more commonly prescribed Suboxone®, which is a combination of buprenorphine and the opioid antagonist naloxone. Suboxone is a unique formulation with naloxone that causes severe withdrawal symptoms when addicted individuals inject it to get high. Physicians who provide buprenorphine treatment for detoxification and or maintenance treatment in office must have special accreditation. The government requires these physicians to have the capacity to provide counseling to patients when indicated or to refer patients to those who do. Treatment of opioid addiction in an office can be cost-effective approach that increases the reach of treatment and the options available to patients. Many patients have life circumstances that make treatment in the office of a physician a better option for than specialty clinics. For example, a recovering addict may live far away from a treatment center or have working hours incompatible with the clinic hours. Addiction treatment is available in the office of a primary care physician, psychiatrist and other specialists, such as internists and pediatricians. Patients stabilized on adequate, sustained dosages of methadone or buprenorphine can function normally. Recovering addicts can hold jobs, avoid the crime and violence of the street culture and reduce exposure to HIV by stopping or decreasing injection drug use and other risky sexual behavior. Patients stabilized on medications can also engage more readily in counseling and other behavioral interventions essential to recovery and rehabilitation.

Y chromosome

The Y chromosome is the sex-determining chromosome in most mammals, including humans. In mammals, it contains the gene SRY, which triggers testis development, thus determining sex. The human Y chromosome is composed of about 60 million base pairs. Most mammals have one pair of sex chromosomes in each cell (though the platypus has five pairs). Males have one Y chromosome and one X chromosome, while females have two X chromosomes. In mammals, the Y chromosome contains the gene that triggers embryonic development as a male. This gene is SRY. Normal sperm production needs other genes, in addition to SRY, on the Y chromosome.

Externally Applied Antibiotics

Externally applied antibiotics such as erythromycin, clindamycin, Stievamycin or tetracycline kill the bacteria that grow in the blocked follicles. While topical use of antibiotics is equally as effective as oral use, this method avoids possible side effects including upset stomach and drug interactions (e.g. it will not affect use of the oral contraceptive pill), but may prove awkward to apply over larger areas than just the face alone.